Given the economic climate, what’s the risk of accepting a job with the first quality practice that makes me an offer?

Every job opportunity that presents itself to you is not a good one. And every practice you talk to will present itself as a quality practice. Practices that know how to recruit are only going to show you the good parts.
And even when the practice is an ideal fit, the community may not be.  Remember, by researching potential opportunities, you can weed out those that might not be a good fit for you.  And by interviewing effectively, you can eliminate additional opportunities that might not meet your needs.